Cited Applications: IHC, WB Species Specificity: human, mouse, rat
Cited Species: human
Positive WB detected in: HeLa cells, DU 145 cells, rat testis tissue, A431 cells, K-562 cells
Positive IP detected in: A431 cells
Positive IHC detected in: human cervical cancer tissue, human testis tissue, human colon cancer tissue Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0
Recommended dilution: WB : 1:500-1:2000 IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB IHC : 1:20-1:200 Product Information
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage. Immunogen Information
Full name: cyclin B2
Calculated molecular weight: 398 aa, 45 kDa
Observed molecular weight: 51 kDa
Gene symbol CCNB2
Synonyms CCNB2, cyclin B2, G2/mitotic specific cyclin B2, HsT17299 Background Cyclin B2 (CCNB2) is a member of cyclin family proteins, which regulate the activities of cyclin dependent kinases (CDKs) and different cyclins function spatially and temporally in specific phases of the cell cycle. Cyclin B2 serves a key role in progression of G2/M transition. Cyclin B2 has been found to be up-regulated in a variety of human cancers, such as adrenocortical carcinoma, breast carcinoma, colorectal adenocarcinoma, pituitary adenoma and gastric cancer. The aberrant expression of Cyclin B2 deregulates spindle checkpoints in the cell cycle and results in chromosomal instability (CIN), one of the signature phenotypes of most cancers. Moreover, serum circulating Cyclin B2 mRNA expression has been found increased in cancer patients and associated with cancer stage and metastasis status.
杭州浩克生物
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