EZHIP兔單克隆抗體

價格￥1800
規(guī)格100ul
貨號HKZ150419
單位支
品牌HaoKebio

產品介紹

產品參數(shù)

資料下載

品牌	商品編碼	商品名稱	規(guī)格	單位	單價
HaoKebio	HKZ150419	EZHIP兔單克隆抗體	100ul	支	1800

EZHIP
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50296?Clone# ?BP6273
Predicted?Molecular Wt:
51kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q86X51
Background:
EZHIP?Inhibits?PRC2/EED-EZH1 and?PRC2/EED-EZH2 complex?function?by?inhibiting?EZH1/EZH2?methyltransferase?activity,
thereby?causing?down-regulation?of?histone?H3 trimethylation?on’Lys-27′?(H3K27me3)?.?EZHIP?limits?the?enzymatic?activity?of
PRC2 and?lessens the?interaction?between the core complex?and?its?accessory?subunits,?but?does?not?interfere with?PRC2
recruitment?to?chromatin.?Deletion?of?Ezhip?in?mice?leads?to?a?global?increase?in?H3K27me2/3?deposition?both?during
spermatogenesis and at?late stages of oocyte?maturation.?This?does?not?affect?the?initial?number?of follicles?but?is?associated?with a?reduction of follicles?in?aging.
EZHIP?is?usually expressed?in?normal testis tissue and?multitumor tissues.?EZHIP?is a?negative?regulator of?histone?H3?methylation.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.??PubMed:31451685.
2.??PubMed:30923826.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded?sections)?analysis?of??human?testis?labelling?EZHIP?with?BP6273.

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