Claudin18.2兔單克隆抗體

價(jià)格￥2200
規(guī)格100ul
貨號(hào)HKZ150395
單位支
品牌HaoKebio

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品牌	商品編碼	商品名稱(chēng)	規(guī)格	單位	單價(jià)
HaoKebio	HKZ150395	Claudin18.2兔單克隆抗體	100ul	支	2200

Claudin18.2
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50272?Clone# ?BP6249
Predicted?Molecular Wt:
28kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P56856-2
Background:
Claudin18.2?(CLDN18.2) is?a?splice?variant?of?the?membrane?epithelial?tight?junctions?protein?Claudin18?(CLDN18)?and?has
been?identified as a?promising?biomarker for targeted therapy. While?upon?malignant?transformation, the?changes?in?cell
polarity?lead to the exposure of CLDN18.2 epitopes.???which?are?suitable?for?targeted?therapy.?Prior?evidence?demonstrates?????that except for GC, CLDN18.2?is?aberrantly?expressed?in various?primary?tumors?and?metastases,?including?pancreatic,?biliary,?ovarian, and?lung adenocarcinomas, which?makes CLDN18.2 a?pan-cancer?target.
CLDN18.2?has a?restricted expression?profile?in?normal tissues,?it?physiologically expresses?only?in the tight junction?supramolecular complex of gastric?mucosa.
Subcellular?location:
Membrane
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?human Claudin18.2?was?used as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Xu?B??etal. J?Gastrointest?Oncol?11:1431-1439?(2020).
2.??Moentenich?V??etal. Oncol?Lett?19:3665-3670?(2020).
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis of ?human stomach?labelling?Claudin18.2 with?BP6249.

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