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- 價格￥1800
- 規(guī)格100ul
- 貨號HKZ150393
- 單位支
- 品牌HaoKebio
產(chǎn)品介紹
產(chǎn)品參數(shù)
資料下載
| 品牌 | 商品編碼 | 商品名稱 | 規(guī)格 | 單位 | 單價 |
|---|
| HaoKebio | HKZ150393 | HLA-G兔單克隆抗體 | 100ul | 支 | 1800 |
|---|
HLA-G
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50270?Clone# ?BP6247
Predicted?Molecular Wt:
38kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P17693
Background:
HLA-G?(HLA-G?histocompatibility?antigen, class?I,?G)?is a?non-classical?MHC?molecule expressed?by trophoblasts?in?placenta,?thymic epithelial cells, and some tumors.?Alternative?splicing?leads?to?generation?of?at?least?six?isoforms,?four?that?are
transmembrane?proteins and two that are soluble.?It?is?an?inhibitory?molecule?involved?in?immune tolerance?and?escape,
originally?studied?for?its?role?in?maternal?tolerance?of?the?fetus?during?pregnancy.?HLA-G?binds?ILT2,?ILT4,?and?KIR2DL4,?playing a?role?in the?regulation of?natural?killer,T, and?monocyte/macrophage cells.?Its?involvement?in?evasion?of?immune?response
makes?it a?potential target for?immunotherapy.
HLA-G?is?mainly expressed?in?placental trophoblastic cells and choriocarcinoma?cells.
Subcellular?location:
Membrane
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?human?HLA-G was?used as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Curigliano, G. et?al.?(2013)?Clin?Cancer?Res?19,?5564-71.
2.?Shiroishi,?M.?et?al.?(2003)?Proc?Natl?Acad?Sci?U?S?A?100,?8856-61.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis of ?human?placenta?labelling?HLA-G?with?BP6247.
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