p40兔單克隆抗體

價(jià)格￥1000
規(guī)格100ul
貨號HKZ150151
單位支
品牌HaoKebio

產(chǎn)品介紹

產(chǎn)品參數(shù)

資料下載

品牌	商品編碼	商品名稱	規(guī)格	單位	單價(jià)
HaoKebio	HKZ150151	p40兔單克隆抗體	100ul	支	1000

p40
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50028?Clone# ?BP6033
Predicted?Molecular Wt:
66kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q9H3D4-2
Background:
p40 antibody?(antibody?recognizing?ΔNp63 only)?is?an?isoform?of?p63,?is?thought?to?function?as?a?stem?cell?factor,?responsible for?maintaining cells?in an?uncommitted state with?regenerative?potential—a?role that?may?be?recapitulated?in tumors
derived from these?cells.
p40?is?normally expressed?in the?basal or?progenitor cell?layer?of stratified?epithelia?(eg.?squamous,?urothelial,?bronchial),
basal cells of some glandular epithelia?(eg.?prostate),?as well?as?myoepithelial?cells?of?breast?and?salivary?glands,?trophoblasts?and thymicepithelial cells.?In tumor tissues,?p40 expression?is specific for?squamous?cell?carcinoma.
?
p40?is equivalent to?p63?insensitivity for?lungsquamous cell carcinoma,?but?it?is?markedly?superior to?p63?in?specificity,?which eliminates a?potential?pitfall of?misinterpreting a?p63-positive?adenocarcinoma?or?unsuspected?lymphoma?as
squamous cell carcinoma.?p40 appears to?be a?more?reliable?marker?for?squamous?cell?carcinoma.
?
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?p40?residues?????within?aa1-100 of?p40 was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?Nonaka?D?et.al, Am?J?Surg?Pathol.?2012 Jun;36(6):895-?9.
2. ?Bishop?JA?et.al,?Mod?Pathol.?2012?Mar;25(3):405-15.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections analysis?of
prostate tissue?labelling
p40 with?BP6033.?Heat
mediated?antigen?retrieval?was?performed?using
Tris/EDTA?buffer?pH?9.0

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