杭州浩克生物DAB緩沖液
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| 品牌 | 商品編碼 | 商品名稱 | 規(guī)格 | 單位 | 單價 |
|---|---|---|---|---|---|
| HaoKebio | HKZ150141 | CDX2兔單克隆抗體 | 100ul | 支 | 600 |
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# ?BX50018?Clone# ?BP6023
?
Predicted?Molecular Wt:
34kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q99626
Background:
CDX2?is a?homeobox gene encoding?nuclear?homeodomain transcriptional factor essential?to?intestinal?organogenesis.?CDX2?is?crucial for differentiation of epithelium?in the?intestine,?pancreas?and?biliary tract.?CDX2?interacts?with?the?tumour?suppressor??genes APC and?E-cadherin, as well?asbcl-2.
?
In the?intestine?(from duodenum to?rectum) CDX2?nuclear?protein?is demonstrated?strongly?and?uniformly?in?all types?of
epithelial cells.?In?pancreas and?biliary tract CDX2?protein?is?demonstrated?in?scattered?ductal?cells.?In tumor?tissues,?CDX2?is?positive?in the?large?majority cases of colorectal and?appendicealadenocarcinomas.
?
CDX2?is a?relatively sensitive and specific?marker for?“intestinal”?adenocarcinomas.?In?the?classification?of?(adeno‐)carcinomas?of the?unknown?primary, CDX2?is an?important?marker?but should always?be?included?in?a?panel.?Also?in?order?to?identify?the???origin of?neuroendocrine tumors,?CDX2?is?useful?in a?panel.
?
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to CDX2?residues?????within?aa1‐100 of?CDX2 was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded?sections)
analysis of?human?colon
tissue?labelling?CDX2 with?BP6023.?Heat?mediated
antigen?retrieval?was
performed?using Tris/EDTA?buffer?pH?9.0
Background?References:
1.?Xin?S, et.al,Oncology.?2007;73(5-6):357-65.
2.?Werling?RW, et.al,Am?J?Surg?Pathol.?2003?Mar;27(3):303-10.
上一篇: Cytokeratin 19兔單克隆抗體下一篇: SOX10兔單克隆抗體
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