杭州浩克生物易降解蛋白提取試劑盒
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| 品牌 | 商品編碼 | 商品名稱 | 規(guī)格 | 單位 | 單價 |
|---|---|---|---|---|---|
| HaoKebio | HKZ150136 | S100P兔單克隆抗體 | 100ul | 支 | 600 |
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# ?BX50013?Clone# ?BP6018
?
Predicted?Molecular Wt:
10kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P25815
?
Background:
S100P?isa?95-amino-acid?protein?and?a?member?of?the?S100?family.?S100P?has?been?shown?to?mediate?tumor?growth,
metastasis and?invasion through the?binding of Ca2+?ions,?receptor for?advanced?glycation?end?products,?cytoskeletal?protein?ezrin, calcyclin-binding?protein/Siah-1-interacting?protein and cathepsin?D.
?
S100P?highly expressed?in?human?placenta, gastrointestinal tract, and esophageal?mucosa?,?but?always?negative?in?pancreas??and?liver.?Overexpression of S100P?has?been detected?in several?cancers?such?as?breast,?colon,?prostate,?pancreatic?and?lung?carcinomas,and the?protein?has?been?functionally?implicated?in carcinogenic?processes.
?
S100P could?potentially serve as diagnostic?marker,?prognostic/predictive?indicator?and therapy?target?for?different?carcinomas.
?
?
Subcellular?location:
Cytoplasma,?nuclear
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide according to the C-terminus?of?S100P?was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of?human?placenta tissue?labelling
S100P?with?BP6018.?Heat ???mediated?antigen?retrieval?was?performed?using
Tris/EDTA?buffer?pH?9.0
Background?References:
1.?Jiang?H?et.al. J?Cancer?Res?Clin?Oncol.?2012?Jan;138(1):1-9.
2.?Seppo?Parkkila?et.al.?BMC?Clin?Pathol.?2008; 8:?2.
上一篇: Topoisomerase II-α兔單克隆抗體下一篇: HER2兔單克隆抗體
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