IMP-3兔單克隆抗體

價格￥1000
規(guī)格100ul
貨號HKZ150410
單位支
品牌HaoKebio

產(chǎn)品介紹

產(chǎn)品參數(shù)

資料下載

品牌	商品編碼	商品名稱	規(guī)格	單位	單價
HaoKebio	HKZ150410	IMP-3兔單克隆抗體	100ul	支	1000

IMP-3
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50287?Clone# ?BP6264
Predicted?Molecular Wt:
64kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??O00425
Background:
IMP-3?is?RNA-binding factor that?may?recruit target transcripts to cytoplasmic?protein-RNA?complexes?(mRNPs).?It?also
modulates the?rate and?location at which target transcripts?encounter the translational?apparatus?and?shields?them?from
endonuclease attacks or?microRNA-mediated?degradation.?IMP-3?binds to?N6-methyladenosine?(m6A)-containing?mRNAs and
increases?their?stability.?IMP-3?Binds?to?the?3′-UTR?of?CD44?mRNA?and?stabilizes?it,?hence?promotes?cell?adhesion?and invadopodia formation?in cancer cells.
IMP-3 expressed?in fetal?liver, fetal?lung, fetal?kidney, fetal thymus, fetal?placenta, fetal follicles?of?ovary,?gonocytesoftestis,?growing oocytes, spermatogonia and semen.?It?also?expressed?in?ovary, testis,?brain,?placenta,?pancreatic?cancer?tissues,
cervix adenocarcinoma,?in testicular?pancreatic and?renal-cell carcinomas.
Multiple studies?have found that?IMP-3?is a?marker of?malignancy?associated with?increased?tumor?aggressiveness?and?decreased overall survival.?It also can?be?used to?distinguish?pancreatic?cancer?from?chronic?sclerosing?pancreatitis.
Subcellular?location:
Cytoplasm/Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?IMP-3 was?used as?an?immunogen. This?information?is?proprietary to
Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?PMID:?16541107
2. ?PMID:?23640942
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded?sections)?analysis of ?human?pancreatic cancer?labelling?IMP-3?????with?BP6264.

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