杭州浩克生物
F4/80 兔單克隆即用型抗體
1131存儲說明: 以藍冰運輸。收貨后，進行分裝，并在-25°C 至-18°C 條件下儲 存。避免反復凍融。 背景參考文獻: 1.?Hirsch, S. et a...
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| 品牌 | 商品編碼 | 商品名稱 | 規(guī)格 | 單位 | 單價 |
|---|---|---|---|---|---|
| HaoKebio | HKZ150128 | CD30兔單克隆抗體 | 100ul | 支 | 600 |
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# ?BX50005?Clone# ?BP6012
?
Predicted?Molecular Wt:
64kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P28908
?
Background:
CD30, TNF-receptor?superfamily?member,?is?a?receptor?for?TNFSF8/CD30L. TRAF2 and?TRAF5?can?interact?with?this?receptor?and ????mediate the signal transduction that?leads to the activation?of?NF-kappaB. This?receptor?is?a?positive?regulator?of?apoptosis,?and?it
also?has?been shown to?limit the?proliferative?potential of autoreactive?CD8?effector T?cells?and?protect the?body?against?autoimmunity.
?
CD30?is expressed?in?mononuclear?Hodgkin’s and?multinucleated?Reed‐Sternberg cells?in?Hodgkin’s disease,?in tumor?cells?of?a?majority of anaplastic?large cell?lymphomas,?in a varying?proportion?of?activated?T?and?B?cells.?In?non-lymphoid?malignancies,???CD30?reactivity?has?been?reported?in embryonal carcinomas?(ECs), seminomas, and?hepatocellular?carcinomas.
?
This antibody?has?been?useful?in?identifying?Hodgkin’s?lymphoma, anaplastic?large cell?lymphomas?(ALCL) and?primary?cutaneous?CD30+ T-cell?lymphoproliferative?disorders.
?
Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to CD30?residues?within?aa495‐C?terminal?of?CD30 was?used?as?an ????immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Watanabe?M., et?al. Am?J?Pathol.?2003 Aug;163(2):633-?41.
2. ?Pileri?SA., et?al. J?Clin?Pathol.?2002?Mar;55(3):162-76.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded sections)?analysis of?human?hodgkin
lymphoma tissue?labelling??CD30 with?BP6012.?Heat ????mediated?antigen?retrieval?was?performed?using
Tris/EDTA?buffer?pH?9.0
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